Immunohistological analysis of Tac antigen expression in tissues involved by Hodgkin's disease

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1392 Regulation of Tac Antigen Expression

Interleukin 2 (IL-2), 1 also known as T cell growth factor, discovered by Morgan et al. (1), is a lymphokine produced by normal peripheral blood lymphocytes after antigen or mitogen stimulation (2, 3) and is required for the proliferation and function of T cells (2, 3), natural killer cells (4-6), and cytotoxic effector cells in vitro and in vivo (7-9). In addition, IL-2 is able to induce or en...

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Proliferating cell nuclear antigen (PCNA), p53 and MDM2 expression in Hodgkins disease.

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Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked t...

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ژورنال

عنوان ژورنال: British Journal of Cancer

سال: 1984

ISSN: 0007-0920,1532-1827

DOI: 10.1038/bjc.1984.191